Endocrine Abstracts

The aim of our study was to assess the effectiveness of radioiodine therapy (RIT) on the reduction of thyroid volume after pre-treatment adjunct of rhTSH in patients with non-toxic goitre with low RAIU.Material and methods: We treated 36 patients; (28 female, 8 male) aged 35–77 years. Initial 24 h RAIU was ranged between 5 and 17%, and thyroid volume ranged between 42 and 128 ml. Twelve patients had compressive symptoms. Malignant changes were exclu...

Gestational diabetes mellitus (GDM) identifies a population of women at high risk of subsequent type 2 diabetes mellitus, representing an early stage in the natural history of the disease. Systemic inflammation is associated with the development of type 2 diabetes but the data concerning pro- and anti-inflammatory cytokines in patients with GDM are limited. The aim of our study was to investigate serum concentrations of interleukin-8 (IL-8), IL-18 and IL-10 in pregnant women w...

In the opinion of the World Health Organization the obesity will become one of four major epidemics of the 21st century. The most important factor for its occurrence is the lifestyle.The aim of the research was to analyse the body mass index (BMI) of pre-school children and their parents and the components of their lifestyle, such as diet, sports and free time activities.Material and Methods: The two-stage study included 537 childr...

Introduction: Results of many studies indicate that BsmI polymorphism in VDR gene may influence bone tissue metabolism and may be useful in identifying patients at greater risk of glucocorticoid-induced osteoporosis.Aim of the study: To determine frequency of polymorphic variants of VDR gene (BsmI) and its relationship to phenotypic features characterizing bone status (BMD and metabolic bone turnover).Material and methods: Followin...

54-year old woman with Graves’ disease was admitted to Endocrinology Department because of severe thyrotoxicosis and antithyroid drugs inolerance. The apathetic form of thyrotoxicosis was diagnosed; she lost 12 kg during 3 months and she had heavy muscle weakness. Previously she demonstrated allergic skin reactions (macular rushes) after both: Methimazole and Propylthiouracil. At admission her TSH was 0.001 mU/l, fT3 24 pg/ml, fT4 37 pmol/l. Lithium, propranolol and gluco...

Stimulation of the corticotropin-releasing factor type 2 receptor (CRFR2) by its putative ligands the urocortins may influence cardiovascular function by regulating vascular tone and angiogenesis.We examined whether chronic exposure to the CRFR2-selective ligand Urocortin 3 altered the ability of the receptor to modulate vascular functions by assessing arterial contractility and angiogenesis in response to Urocortin 3 both in control mice and in transgen...

Most authorities recognise adult growth hormone deficiency (AGHD) as a distinct endocrine disorder, although determining an appropriate strategy for optimising replacement remains controversial.We reviewed the outcome of a cohort of patients treated with a fixed graded initiation phase followed by an individualised titration phase. Patients were initiated on a starting dose of 0.3 mg recombinant human growth hormone (rhGH) for one month, with increases t...

Introduction: CHEK2 mutations are associated with increased risk of having neoplasms of various organs, including thyroid, breast, colon, renal and ovarian cancers. Coexistence of thyroid and breast cancers was observed in female carriers of CHEK2 gene mutations. In polish population the most common mutations are those truncating CHEK2 protein (1100delC, IVS2+1G>A, del5395) and a missense I157T CHEK2 mutation. Carrying missense I157T mutation is connected with having twice...

Introduction: Isolated corticotropic insufficiency of hypophysis with consecutive secondary adrenal insufficiency is a very rare disease. Literature notes difficulties in proper recognition and necessity of differential diagnosis, including among others chronic fatigue syndrome. In recent years, in Poland we observe more and more frequently setting this diagnosis – only on the basis of low ACTH an cortisol concentrations, despite of proper stimulation with 250 μg<sup...

Adrenocortical carcinoma (ACC) is a rare malignancy. Authors present three cases of even less commonly encountered manifestation of ACC. Case 1: A 39-year-old male, with decompensated hypertension, was admitted to Department of Endocrinology due to a large tumor of the left adrenal gland (65 mm) revealed in the CT of the abdomen. Non-contrast attenuation was 35HU. After performing MRI with chemical shift, tumor was classified as non-adenoma as there was no significant loss of ...